In what ways might the meaning of the message when it was sent differ from the meaning when it was received, and what are the key technical or non-technical issues that might influence the magnitude of the gap, if one exists?
To answer this question you need to first identify either technical OR non-technical issues that might result in the receiver of a message understand a different meaning than the one that was intended by the sender.
Technical issues might include a lot of disruption "noise" interrupting the message, the medium of exchange or other related problems.
Non-technical issues might include cultural assumptions, lack of understanding of the language used in the message etc.
Having made the case for the key issues, you need to show the way in which that/those issues might influence or effect the level or amount of difference between the meaning that was intended and the meaning that was received.
A: You need to first identify the influencers that you believe to be key, and show how and why you made that determination, and then having made that determination discuss how it might influence the gap between the message sent and the message received. The number of influencers (technical or non-technical) that you select is part of the argument that you need to make in the first section.
NB. The question asks for technical or non-technical influences, not technical and non-technical influences.