Nursing Clinical Guidelines and Literature ReviewBoth articles have used a randomized prospective trial. The questions under study have clearly focused on the population studied, the intervention given and outcomes considered. For example, in the first article, surgical site infection following colorectal cancer surgery, occurring in 300,000 to 500,000 subjects from a research done in USA each year while in article two, standard wound care for primary closed vascular surgical wounds, studied 160 subjects who received Aquacel dressing. The subjects randomly received surgical incision dressed with Aquacel Ag Hydro fiber dressing (ConvaTec) in the experimental arm. The efficacy outcome of the research is the occurrence of any SSI within 30 days after surgery.Both articles preferred the randomized controlled trial because it compares the efficacy of different types of doses of systematic antibiotics for preventing SSIs and the influence of different preoperative skin antiseptic potential for author bias. The study`s randomization procedure was appropriate.